Background: Gastric and esophageal cancer are common and have high incidence mortality. Multiple risk factor such as smoking, alcohol intake, hot food and beverage intake has been related to development of squamous cell carcinoma, while obesity, gastroesophageal reflux (GERD) and Helicobacter Pylori (H. pylori) infection has been related to development of adenocarcinoma. The aim of this case report is to find out the possible risk factor of gastric and esophageal cancer that occurs in patients with multiorgan metastases. Case Presentation: A male, 42 years old, Balinese, came to the hospital with complaints of abdominal pain, nausea, fatigue, and weight loss. Patient had history of alcohol consumption, every day for 5 years. On physical examination anemic sclera and ascites were found. Complete Blood Count (CBC) showed anemia (2.6 g/dL). Esophagogastroduodenoscopy (EGD) were performed and found tumor on esophagus and gaster. Abdominal Computed Tomography scan (CT-scan) with contrast and ultrasonography showed a solid mass attached to lien and corpus pancreas that were suspected as malignant, ascites, pericardial effusion and hepatomegaly with multiple nodules, suspected hepatocarcinoma due to metastasis, respectively. Thorax X-Ray showed left pleural effusion, suspected due to metastasis. Patient had received symptomatic therapy and packed red cell transfusion. Conclusion: The diagnosis of gastric and eshophageal cancer begins with history taking, physical examination, supportive investigations. Histopathological examinations were required to select appropriate and proper therapy.