Background and objective: The aim of the study is to compare and evaluate the post-operative analgesic efficacy of diclofenac transdermal patch over the diclofenac sodium tablet after the mandibular molar extraction under a randomized controlled clinical study. Methods: 100 healthy individuals of both the sexes, age ranging between 18-40 years who are indicated for mandibular molar extractions are included in the study. Patients were divided randomly in to two groups with 50 each. Group A patients were received DICLOFENAC TABLET 50mg twice daily for three post operative days. Group B patients received DICLOFENAC TRANSDERMAL PATCH 100mg once daily for three post operative days. Post operative pain scores were recorded using VAS scale for the next three post operative days. Conclusion: From this study we can arrive at a conclusion that, pain management was better with oral diclofenac tablet after 6 hours after the extraction. After the 12 hours, both the drug delivery systems provided equal analgesic effect. When compared overall analgesic performance of oral diclofenac tablet and transdermal patches after tooth extraction for three post operative days, diclofenac tablet provided slightly better results than the transdermal patches, which was statistically significant.