A comparative study of the isothermal kinetic release of diclofenac drug from chitosan-acrylic acid and chitosan-acrylic acid-co-2-methacryloyloxyethyl trimethylammonium chloride hydrogels was conducted. The kinetic release curves of diclofenac from the hydrogels in distilled water at various temperatures (20-42 degrees Celsius) were determined. The ranges of drug release reactions were identified using initial amounts, saturation levels, and the empirical equation designed by Peppas and colleagues. The widely-used proportional model was employed to determine the kinetic models for both drug release and the swelling of an external solvent into the hydrogel. It was found that the kinetics of diclofenac release from both chitosan-acrylic acid hydrogels and chitosan-acrylic acid-co-2-methacryloyloxyethyl trimethylammonium chloride hydrogels could be better described by the first-order chemical reaction pattern. The drug release process was analyzed to determine the kinetic parameters, which uncovered noteworthy variations in the values between chitosan-acrylic acid and chitosan-acrylic acid-co-2-methacryloyloxyethyl trimethylammonium chloride hydrogels. The kinetic impact on the drug density was described using a first-order chemical reaction model for chitosan-acrylic acid-co-2-methacryloyloxyethyl trimethylammonium chloride hydrogel, while the chitosan-acrylic acid hydrogel was better characterized by a diffusional pattern, indicative of a diffusion-controlled process in a phase-controlled environment. The performance of a novel molecular transfer process for drug release was investigated based on the consistent correlation of kinetic parameters (lnA, Ea) with the released diclofenac amount (α), incorporating a compensatory effect. According to this mechanism, drug release is seen as the disengagement of the drug from active separation centers within the sub gel/hydrogel with varying energies. A process was designed to determine the performance of the activation energy distribution. The performance of different activation energy distributions for chitosan acrylic acid and chitosan-acrylic acid-co-2-methacryloyloxyethyl trimethylammonium chloride hydrogels was determined.