Background: Chronic Obstructive Pulmonary Disease (COPD) is a progressive lung condition associated with systemic inflammation and oxidative stress, which may influence metabolic markers like uric acid and C-reactive protein (CRP). Elevated serum uric acid and CRP levels, as well as the serum uric acid to creatinine ratio (SUA/Cr), have been linked to inflammatory diseases. However, their role in COPD remains unclear. Introduction: This study aims to compare serum levels of uric acid, CRP, and the SUA/Cr ratio between COPD patients and a healthy population, investigating their potential role as biomarkers for disease severity and progression. Methodology: A cross-sectional comparative study was conducted on 50 COPD patients and 50 healthy controls. Serum uric acid, CRP, and creatinine levels were measured, and the SUA/Cr ratio was calculated. Statistical analysis was performed to assess differences between the groups and correlations with disease severity in COPD patients. Results: COPD patients showed significantly higher levels of serum uric acid, CRP, and SUA/Cr ratio compared to the healthy control group. A positive correlation was found between these biomarkers and the severity of COPD, indicating their potential as markers of inflammation and disease progression. Conclusion: The study highlights that elevated serum uric acid, CRP, and SUA/Cr ratio are associated with COPD and its severity. These markers could be useful in monitoring disease progression and tailoring treatment strategies in COPD patients