Objective: The objective of this study is to compare the disintegration times of Mefenamic Acid tablets formulated with two different disintegrating agents: croscarmellose sodium and crospovidone. The aim is to determine which disintegrant provides a more rapid disintegration time, which is crucial for the drug's onset of action and overall bioavailability. Materials: Mefenamic Acid, Disintegrants: Croscarmellose sodium (CCS), Crospovidone (CP), Other Excipients: Lactose, microcrystalline cellulose, magnesium stearate, and other standard tablet excipients, Equipment: Tablet compression machine, disintegration tester, analytical balance, and other laboratory apparatus. Method: Formulation: Two batches of Mefenamic Acid tablets were prepared. Batch A used croscarmellose sodium as the disintegrant, while Batch B used crospovidone. Tablet Compression: Tablets were compressed using a tablet press, ensuring uniform weight and size. Disintegration Test: Tablets from both batches were subjected to disintegration testing as per the USP guidelines. The test was performed using a disintegration tester, and the time taken for the tablets to completely disintegrate in the medium was recorded. The medium used was typically distilled water maintained at 37°C ± 0.5°C. Each test was conducted in triplicate to ensure accuracy and consistency.