Bone is a specialized connective tissue, consists of cells, fibres & intercellular matrix. Bone at the tissue level undergoes remodeling: it is continuously being resorbed and rebuilt (or formed). A negative balance between bone resorption and formation, frequently due to excessive resorption is the basis of many bone diseases. Resorption is carried out by osteoclasts, which are specialized multinucleated cells of hemopoietic origin. Bone resorption takes place at a specialized area of the osteoclast cell membrane called "ruffled border," which comprises a sealed lysosomal compartment where the acidic pH solubilizes the mineral and the proteolytic enzymes digest the matrix. Calcitonin and bisphosphonate have been shown to act directly on osteoclasts whereas other hormones and agents probably act on the osteoblasts or cells of the osteoblast lineage. Whenever there is a breach in the continuity of bone, it undergoes stepwise healing process and if the bone is missing or it could not heal then the bone grafting needs to be done. There are three types of procedures for bone grafting; Autograft, Allograft, and Synthetic bonegraft. Growth factors are also play roles in bone grafts and they consist of either human growth factors or morphogens (BMPs in conjunction with a carrier medium, such as collagen). As the bone grafting is commonly used to augment bone healing and repair that is why the present review has been conducted to bridge the knowledge of basic science and clinical implication of various bone constituents with its function, bone healing process, various grafts and its advantage and disadvantage.