In this study, sodium starch glycolate and crospovidone, two artificial super disintegrants, are compared to the natural super disintegrant psyllium husk in orodispersible tablets (ODTs). A natural, affordable, and biodegradable alternative called psyllium husk was compared to popular synthetic super disintegrants that are renowned for their quick disintegration speeds. The mechanical strength, disintegration time, and dissolving rate of the formulations were evaluated. The results indicated that psyllium husk had equivalent performance with the added advantages of being natural and non-toxic, whereas synthetic super disintegrants produced quicker disintegration and greater dissolving rates. The results show that psyllium husk can be a sustainable and workable substitute for synthetic super disintegrants in ODT formulations; nevertheless, more tuning is required to maximize its potential.