Introduction: Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are indicated in the treatment of various acute and chronic inflammatory conditions and also concomitant with antimicrobial agents. Recent studies have shown that NSAIDs are most commonly prescribed in orthopaedics and medicine wards in hospitals and the proportion of geriatrics, the most common group to be admitted in hospitals. They have at least one chronic disease and have more comorbidity. Hence, while prescribing NSAIDS in elderly, it is given along with multiple other drugs. Polypharmacy exposes elderly patients to increased risk of drug-drug interactions, monetary issues and adverse drug events, thus jeopardizing the therapy. This present study highlights the various comorbid conditions amongst the geriatric population (above 65 years of age). However, an inter-professional strategy can be one of the most effective interventions for addressing polypharmacy.