Aloe vera, one of the most versatile medicinal plants, has been widely popularized in the field of green synthesis due to its phenomenal characteristics. This can be further discussed in the present review paper concerning the comprehensive analysis of Ag and Cu codoped ZnO nanoparticles and their potential benefits. The use of aloe vera extract as a source for green synthesis is a viable and environmentally friendly choice for traditional chemical reconstruction approaches. In this review, the primary properties of codoped nanoparticles are reviewed based on their structure, optics, and morphology, which promote their physicochemical properties in comparison to those of doping-free nanoparticles. This article investigates how the synergistic effect of codoped ZnO manifests improved catalysis, disinfection, and photocatalysis. Moreover, the review also covers the potential applications of these promising nanostructures in many fields, such as environmental remediation, biomedical applications, and energy storage devices. The outcome of this review paper will add value to the increasing literature based on the potential of aloe vera-mediated green synthesis for the development of composite materials for various advanced functional materials as a sustainable and eco-friendly solution.