Background and aim: The main aim of this review paper to make Nano sponges which will be loaded with orange peel oil to improve its antifungal activity. Citrus sinensis, the sweet orange from which orange essential oil is extracted, has a variety of pharmacological and clinical effects that have made it one of the most significant natural oils in the pharmaceutical industry. Terpenes, flavonoids, carotenes, and coumarins are thought to be the source of the plant's potent antimicrobial (especially antifungal), antioxidant, analgesic, and insecticidal properties. Citrus essential oils (EOs) are also used in air fresheners, household cleaning products, perfumes, cosmetics, and medicines because of their pleasant, reviving aroma. However, orange peel essential oil (EO) contains 0.035-0.073% of non-volatile substances that can irritate the skin and cause photosensitivity. This review paper aims to create orange-loaded nano sponges with a topical hydrogel that have an improved antifungal effect and reduced irritation to overcome these issues. Poorly water-soluble medications will have their aqueous solubility improved by nano sponges, and they will release their molecules in a controlled way. They are employed to remove poisonous substances from the body, lessen side effects, and consequently reduce the frequency of dosing. Nano sponges will increase both the formulation's flexibility and stability. They have better patient compliance and are non-toxic, non-irritating, and non-mutagenic. Due to the nano sponges' small pore size and self-sterilizing properties, bacteria cannot penetrate them.