Nasopharyngeal carcinoma is a multifactorial disease mainly affecting the Asian and North African populations including Morocco. Aimed: To determine the epidemiological profile of nasopharyngeal carcinoma in central india as well as its clinicopathological, therapeutic, and prognostic characteristics. Materials and Methods: We analyzed our hospital data between January 2018 and December 2024 with NPC and analyzed their demographic parameters and outcomes with therapy. Results: Nasopharyngeal carcinoma (NPC) represented 5% of all cases with a median age of 47. The most affected age group was 40–55 years (38%). Of all patients, 68% were men and 32% were women with a sex ratio of 1.9 (Male/Female). Undifferentiated nasopharyngeal carcinomas were the most common histological type affecting 92% of patients. At diagnosis, the majority of patients (96%) had an advanced stage of NPC (III, VIa, b, c) including 4% of metastatic cases (IVc). Most cases (92%) had lymph node involvement with cervical mass being the most common clinical presentation. 82% of patients received radiotherapy combined with chemotherapy. Among these patients, 44% had concurrent radiochemotherapy preceded by induction chemotherapy. The 5-year overall survival (OS) was 86% for all patients. It represented 90% for early stages, 86% for locally advanced stages, and 54% for the metastatic stage significantly. Conclusions: Nasopharyngeal carcinoma is a particular disease with a late declaration. It is common in Morocco as is the case in other endemic areas with a high prevalence. Patients’ survival is significantly influenced by disease staging.