Nack ground:-Type 2 diabetes mellitus (T2DM) is a common metabolic disorder in Pakistan. It is often associated with dyslipidemia, which increases cardiovascular risk. Routine practice mainly focuses on fasting lipid levels, while postprandial lipid changes are less explored, despite their clinical relevance. Objective: To compare fasting and postprandial lipid profiles in patients with type 2 diabetes mellitus and non-diabetic controls, and to assess the significance of postprandial lipid abnormalities. Methods: This comparative study was conducted at Avicenna Medical College Hospital, Lahore. A total of 200 participants were enrolled, including 100 known T2DM patients and 100 non-diabetic controls, aged 30–50 years. Fasting and six hour postprandial blood samples were analyzed for total cholesterol, triglycerides, HDL-C, LDL-C, and VLDL. Glycemic parameters included fasting blood sugar and HbA1c. Statistical analysis was performed using t tests and repeated measures ANOVA, with p < 0.05 considered significant. Results: Conclusion: Patients with T2DM showed significantly higher fasting and postprandial triglycerides, LDL-C, VLDL, and lower HDL-C compared to controls (p < 0.0001). Postprandial triglyceride and VLDL levels were markedly elevated in diabetic patients compared to their fasting values, while total cholesterol and LDL-C showed relative reduction after meals. Poor glycemic control was associated with more pronounced lipid abnormalities. Type 2 diabetes mellitus is associated with significant fasting and postprandial dyslipidemia. Postprandial lipid assessment reveals additional atherogenic risk not evident in fasting samples alone. Routine evaluation of postprandial lipid profiles should be considered for better cardiovascular risk assessment in patients with T2DM.