Background: Acute pancreatitis is a prevalent surgical condition, frequently attributable to non-alcoholic etiologies. Determining the underlying cause is essential since management strategies vary accordingly. One such diagnostic parameter is the estimation of the serum lipase to serum amylase ratio. This study aims to evaluate the utility of this ratio in differentiating between alcoholic and non-alcoholic etiologies in patients presenting with clinical and radiological evidence of acute pancreatitis at our tertiary care center.