Mental disorders account for 13% of the global disease burden, affecting more than 970 million people worldwide in 2017. About 1 in 17 individuals suffer from serious psychosis globally, making them dependent on caregivers whose wellbeing is directly related to the life and quality of care they provide. This study aims to assess, correlate and associate the level of stress, family burden, and coping mechanisms among family caregivers of patients with mental disorders in a selected mental hospital in Lucknow. A cross-sectional descriptive study was conducted using structured questionnaires to measure stress levels and coping mechanisms among caregivers. The study found that the majority of family caregivers of patients with mental disorders experienced moderate to high levels of stress. Social support and personal resilience were the most commonly used coping mechanisms and were significantly correlated with lower stress levels. The study concludes that caregivers experience significant stress, necessitating targeted interventions to support their wellbeing and improve patient care outcomes.