A study to assess the effectiveness of self-instructional module on knowledge regarding prevention of adverse effects of mobile phone games among nursing students at SRM College of Nursing, Kattankulathur, Chengalpattu District.” The objective of the study were to assess the pre-test knowledge of students regarding prevention of adverse effects of mobile phone games, to evaluate the effectiveness of self-instructional module knowledge of students regarding prevention of adverse effects of mobile phone games and to find out the association between post-test level of knowledge with their selected demographic variables of student.To determine the sample (N = 130), an evaluative method using a pre-experimental one-group pre-test and post-test design was employed. The knowledge was evaluated using a systematic knowledge questionnaire, and the efficacy of SRM College of Nursing was determined. Analyses of the gathered data were conducted using both descriptive and inferential statistics. The knowledge mean score for the pretest was 12.84±4.51, while the knowledge mean for the posttest was 20.32±2.59. At the p<0.001 level, the computed paired "t" test value of t = 17.537 was determined to be statistically highly significant. This indicates unequivocally that giving nursing students a self-instructional module on the prevention of negative mobile phone effects was found to be successful in raising their post-test knowledge level. The pretest mean score of PPBS was 174.20±16.28 and the posttest mean score of FBS was 174.0±15.87 for the control group. At the p<0.05 level, it was determined that the computed paired "t" test value of t = 0.494 was not statistically significant. The study's findings showed that, when it came to preventing the negative impacts of mobile phones, 75 people (57.69%) had insufficient understanding and 25 people (19.23%) had moderate understanding during the pretest. On the post-test, however, 32(24.62%) and 68(52.31%) reported having adequate and moderate knowledge, respectively.