Background: Back pain is a widespread occupational musculoskeletal disorder among healthcare workers globally. It is one of the most frequently reported musculoskeletal problems. Research consistently shows that medical practitioners experience LBP more frequently than other symptoms. Aim: The study aimed to assess the quality of life of staff nurses with back pain in selected hospital, Chennai. Methods: Cross section design was used for the study. The study was conducted among 124 staff nurses who are working in a selected hospital at Chennai. The samples were selected using a convenient sampling technique who fulfils inclusion criteria. Finding: The study revealed that 40% of the staff nurses reported a low quality of life, while the majority, 52%, experienced a moderate quality of life. Only 8% of the staff nurses indicated a high quality of life. This distribution highlights the significant impact of occupational factors on the overall well-being of healthcare professionals. Conclusion: The study concluded that pain severity and functionality scores indicate moderate levels of discomfort and difficulty in daily activities. Quality of life aspects reveal moderate to high limitations in various areas, with social interaction scoring notably high.