The traditional medicinal herb Semecarpus anacardium, which is utilized extensively in many indigenous medical systems, has drawn interest due to its possible therapeutic uses. The purpose of this review is to compile and assess the available scientific data on Semecarpus anacardium's potential anti-inflammatory and anti-carcinogenic properties. The plant's active ingredients include a variety of bioactivities and are mostly found in the fruit and nut. According to studies, Semecarpus anacardium has strong anti-inflammatory properties. These benefits may be related to its capacity to block important inflammatory mediators and enzymes.