Acrylamide (ACR) is a water soluble white crystalline solid commonly used in industries that has neurotoxic effects. ACR is found in food items that are cooked under high temperatures. Lumbricus terrestris (common earthworm) was selected as the target organism as it also has ‘Central Nervous System’. Erythrina indica’ was used as an inhibitory drug, as it has Anti-inflammatory properties and is beneficial for the nervous system. The present study attempts to assess the neurotoxic effects in cerebral ganglions along with the morphological, locomotory and neurological behavior of Lumbricus terrestris on Acrylamide intoxication along with the inhibitory effect of Erythrina indica.