Introduction: The healing of oral mucosa wounds is a dynamic process that involves a sequence of events orchestrated by intricate cellular interactions. Objectives: The main objective of the study is to find the role of aloe vera gel that accelerates vasculogensis in wounded oral mucosa, a special study using CD34 Immunohistochemical (IHC) stain. Material and methods: An experimental animal study was conducted at the Experimental Research Laboratory of Postgraduate Medical Institute Lahore to study the histological changes in tongue mucosa wounds at 5th and 7th day post wounding. The therapeutic reagent used in this study was Aloe vera (Aloe barbadensis Miller) gel. Day 5 & 7 pw were selected to see the prolonged effects of the drug on the healing tissue.