Varicose vein is one of the most annoying disease occurring all over the world. People who are standing and sitting for a longer period of time such as teachers, bank staffs, hair dressers and nurses are more prone for the risk of varicose veins. This study was conducted on finding out risk factor of varicose vein among nurses and to provide information booklet on prevention of varicose vein. Objectives: To identify the risk factors of varicose veins among staff nurses assessed by risk assessment scale. To find out the association between risk factors of varicose vein and socio-demographic variables and to develop an information booklet on prevention of varicose vein. Methodology: A descriptive study was conducted among 80 staff nurses to identify the risk factors of varicose veins in selected tertiary care hospitals, Belagavi using self administered checklist. The study was conducted using Purposive sampling technique. Result: In the present study the frequency and percentage of demographic data of respondents regarding risk factors of varicose veins, where majority of respondents 58 (72.50%) belonged to the age group of ≤30 years. Majority of participants 53 (66.25%) were female. In relation to the educational status of the respondents 59 (73.75%) were diploma. Majority of the subjects, years of experience was between 5-6years and ≥7years were 31 (38.75%) respectively. Majority of the participants, BMI include 62 (77.50%) were non obese. About 60 (75%) of the respondents were mixed diet. Majority of the participants 71 (88.75%) were not smoking. Majority of the subjects 73 (91.25%) were not consuming alcohol. Statistical analysis using chi-square to find association between the risk factors and selected socio demographic variables revealed that there was significant association between risk factors and years of experience of participants at 0.05 level of significance as P value is <0.05. This indicates that risk factors were dependent on years of experience of the respondents. But no significant association was found between the risk factors and selected demographic variables like age, gender educational status, BMI, diet, smoking habits and alcoholism at 0.05 level of significance as p value is >0.05. The variables and risk factors were independent on each other. Conclusion: The study concluded that the risk factors of varicose veins and years of experience showed significant association and there was no significant association between risk factors and other socio demographic variables such as age, gender, educational status, BMI, diet and habits, where prolonged standing leads to varicose veins so nurses are more prone to adapt this disease and preventive measures plays a vital role in avoiding varicose veins.