Fat is a filler with ideal properties: it naturally integrates into tissues, is autologous, and is 100% biocompatible. However, this is not the only function of lipofilling; fat is an active and dynamic tissue composed of several different cell types, including adipocytes, fibroblasts, smooth muscle cells, endothelial cells, and adipogenic progenitor cells called “preadipocytes”[1]. Adipose-derived stem cells (ASCs) have a differentiation potential similar to that of other mesenchymal stem cells as well as a higher yield upon isolation and a greater proliferative rate in culture when compared to bone marrow–derived stem cells. Because of these properties and because these cells can be easily harvested in great amounts with minimal donor-site morbidity, ASCs have proved to be particularly promising for regenerative therapies [2].