The study investigates the efficacy of nanocomposites in combating bacterial infections and their photocatalytic activity. Silver (Ag) and zinc oxide (ZnO) nanoparticles were synthesized and integrated into a N-isopropylacrylamide (NIPAM) polymer matrix, with polyvinyl alcohol (PVA) as the coating agent. The resulting Ag-conjugated PNIPAM (Ag-PNIPAM) and Zn-conjugated PNIPAM (Zn-PNIPAM) were thoroughly analyzed using energy dispersive X-ray spectroscopy (EDXS), transmission electron microscopy (TEM), particle size analysis, and zeta potential determination. Particle size distribution confirmed nanoscale dimensions and the stability of the synthesized nanomaterials.