The worldwide occurrence of epilepsy is increasing and it is more challenging in pregnant woman. The challenges are to maintain a balance between benefits and potential risks of pharmacotherapy to avoid the teratogenecity associated with prenatal exposure to AEDs for a developing fetus and the need for effective treatment of maternal health conditions. Epileptic women patients may also be at greater risk for suboptimal prenatal care owing to altered hemodynamic and volume of distribution during pregnancy. Main body of abstract This study used the Maximal Electroshock technique in an experimental rat model to compare the anticonvulsant characteristics of M. pruriens to safer alternatives that were prescribed to pregnant females. The study comprises of following groups Control, M. pruriens (100 mg/kg), and standard medication as per global guidelines i.e., Lamotrigine (20 mg/kg), in female Albino wistar rats. Conclusion The MES results indicated significant anticonvulsant activity as compared to standard drug utilized in the experimental model.