Female infertility is a well-known health issue over the world including Africa; it presents a particularly vexing clinical problem and contributes to infertility among female through the use and or abuse of medications. Dextromethorphan (DM) is a dextro-rotatory isomer of levophanol and a major constituent of over 125 over the counter (OTC) cough syrups. There is a wide spread abuse of Cough syrups in Nigeria particularly amongst adolescent females, which have been reported to have anti-fertility properties. The availability of OTC drugs is facilitated by pharmacies and increasing number of convenience stores and most recently the internet. The aim of this study is to determine the effect of (DM) on female reproductive system using Sprague-Dawley rats as models Twenty rats were used and grouped into four, designated as A-D (155±20g; N=20, A-D). Group A served as control that received 0ml of DM, Groups B-D received 20, 40 and 80 mg/kg respectively for 28 days. At the end of treatment period, the animals were euthanized, the organs (Ovaries and Uteri) were harvested for histology and oxidative stress markers. Blood was collected and stored for hormonal milieu. Results showed increase in MDA and decrease in SOD, CAT and GSH values of both uteri and ovaries when treatment groups were compared to control. Sections showed sloughed epithelial cells with moderate infiltration of the endometrial stroma by inflammatory cells in the uterine and there was decrease in hormonal parameters checked among the treatment groups This study suggests that DM has a deleterious effect on the reproductive hormones, as well as cause damages to ovaries and uterus in females and in-turn lead to infecundity.