This study investigated the antioxidant and neuroprotective properties of the methanolic extract of whole plant ofBoswellia serratacodenamed asBSWP-M. The antioxidant capacity was assessed using the ABTS radical decolorization assay and the hydroxyl radical scavenging activity (HRSA) assay. BSWP-M exhibited significant antioxidant activity, with an IC50 value of 133.87 µg/mL in the ABTS assay, indicating its capability to scavenge free radicals effectively, though it was slightly less potent than ascorbic acid and quercetin, which had IC50 values of 109.07 µg/mL and 99.76 µg/mL, respectively. In the HRSA assay, BSWP-M showed an IC50 value of 122.87 µg/mL, demonstrating considerable hydroxyl radical scavenging activity.The anti-inflammatory neuroprotective potential of BSWP-M was evaluated by measuring its effects on intercellular ROS levels as well as the production of pro-inflammatory cytokines IL-6, IL-1, and TNF-α in RAW264.7 cells. Treatment with 100 mg/mL BSWP-M resulted in significant inhibition of cytokine production, with inhibition rates of 69.87%, 55.93%, and 61.84% for IL-6, IL-1, and TNF-α, respectively (p < 0.001).These findings highlightedBSWP-M as a promising natural agent with substantial antioxidant and neuroprotectiveactivities.