Currently, adipokines have been reported to be associated in chronic inflammatory response. Therefore aim of the study is to assess the level of pro inflammatory biomarker chemerin in saliva in periodontitis patients with and without diabetes mellitus and their association with periodontal health and disease. METHODS: The study included 30 participants. Based on clinical and radiographic periodontal findings, they were categorised into 3 groups; the healthy group ( group1; n=10), periodontitis without diabetes group ( group 2; n=10), periodontitis with diabetes mellitus group ( group 3; n=10). Salivary samples were collected from the participants and were quantified using an enzyme- linked immunosorbent assay. RESULTS: The mean concentration of chemerin in saliva was increased consistently as the disease progressed from healthy state to periodontitis. It was highest in group 3 and lowest in group 1. Mean concentration of chemerin in group 1 was 115.32ng/ml, 475.71ng/ml in group 2 and 554.81ng/ml in group 3 respectively. CONCLUSIONS: In all the three groups, chemerin concentrations were positively correlated. Therefore, chemerin can be used a diagnostic biomarker of inflammatory activity in periodontitis. However large scale studies are needed to confirm more positive associations.