Background: Recently, the presence of vascular abnormalities in patients with multiple sclerosis had been reported. Endothelial dysfunction secondary to inflammatory activity and global cerebral hypoperfusion which might predispose them to the development of ischemic stroke may be a proposed mechanism. Objectives: To assess atherosclerotic changes in a Sample of Egyptian MS patients using different laboratory and radiological markers as well as correlating these changes with patients' clinical symptoms. Patients and Methods: 45 multiple sclerosis patients and 45 healthy controls were enrolled. They underwent clinical assessments using cognitive scales, EDSS. Serum IL17A as common inflammatory marker and structural and vascular imaging were done. Results: Serum IL17 analysis revealed higher levels in cases group compared to control group and these findings revealed statistacal significant difference (ρ-value <0.05). Also, there is a statistically significant difference in the Arterial spin labeling results and vascular ultrasonography between the two groups.