The investigator conducted a descriptive survey with the objectives to assess the quality of life to identify coping strategies adopted by the school going children, and to determine relationship between quality of life and coping strategies adopted by the school going children with thalassemia attending in selected hospital, West Bengal. The conceptual framework of the study was based on sister Callista Roy’s Adaptation Model (1976). Nonprobability convenience sampling technique was adopted to select 100 participants. An un-structured interview schedule for demographic characteristics, standardized Pediatric Quality of Life Inventory TM Version 4.0 used to measure quality of life and standardized Kid COPE used to determine the coping strategies. The findings of the study revealed that among 100 respondents, 50% respondents had favourable quality of life and 50% respondents had unfavourable quality of life. Domain wise unfavourable quality of life was in physical domain 55%, in emotional domain 45%, in social domain 49% and in school domain 36% whereas favourable quality of life was in physical domain 45%, in emotional domain 55%, in social domain 51% and in school domain 64%. The majority (66%) respondents adopted moderate coping strategies, 14% adopted high coping strategies and only 20% respondents adopted low coping strategies. A significant association was found between quality of life and selected demographic variables like age ( 2 = 8.04), educational qualification ( 2 = 6.28) and blood transfusion ( 2 = 7.70) with school domain. The study has several implications in the field of nursing practice, education, administration and research. The study was conducted with the recommendations for conducting with larger samples for better generalization of findings.