Purpose This study aimed to evaluate the effect of Neodymium-doped Yttrium Aluminum-Garnet (Nd: YAG) laser capsulotomy on retinal vessel perfusion densities and macular thickness using optical coherence tomography angiography. Patients and methods The study included 35 eyes of 35 participants with an average age of 70 years old. The participants having posterior capsule opacification were non-diabetic. The preoperative evaluation included history taking, ophthalmological examination and OCT-A was done. All patients underwent YAG laser posterior capsulotomy and then macular thickness and retinal microvascular changes were assessed at one month using OCT-A. Results There was significant improvement of Best Corrected Visual Acuity (BCVA) (Decimal) post laser capsulotomy (P< 0.001), No significant change was determined before and after capsulotomy in macular thickness measurements, and Perfusion density in parafovea and perifovea layers. (All p > 0.05). Conclusion Nd-YAG laser capsulotomy for posterior capsule opacification is considered to be a safe procedure and has no visible effect on macular thickness measurements, flow areas, and vessel perfusion densities.