This study explores the use of Carum carvi (caraway) extract to enhance the bioavailability and efficacy of valsartan, an angiotensin II receptor blocker, in transdermal drug delivery systems. Various solvent extracts of Carum carvi were incorporated into valsartan-loaded transdermal patches, and their effects were assessed through physicochemical and bioactivity evaluations. Among the extracts, the ethanolic extract (F5) demonstrated the highest bioavailability, with a significant increase in drug absorbance (3.19) and cumulative drug release (CDR) of 66.13%. FTIR analysis confirmed no significant interactions between valsartan and the extracts or polymers. The study concludes that Carum carvi extract, particularly in ethanolic form, effectively enhances the transdermal delivery of valsartan, offering valuable insights into the use of phytomedicine and nanotechnology in improving drug delivery systems. These findings suggest potential for better management of chronic conditions like hypertension. Future research should explore the long-term stability and clinical efficacy of these formulations.