ISSN : 2663-2187

Association Between Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) And Helicobacter Pylori Infection on The Incidence Of Peptic Ulcers

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Muhammad Zulfitrah , Susanto Hendra Kusuma , A. Muh. Luthfi Parewangi , Syakib Bakri , Femi Syahriani , Arifin Seweng
» doi: 10.48047/AFJBS.6.14.2024.9760-9767

Abstract

Background: Peptic ulcer is defined as damage to the upper gastrointestinal mucosa resulting in ulcer formation that extends to the submucosal layer. Helicobacter pylori act by producing various enzymes to damage gastric defenses resulting in chronic inflammation while NSAIDs inhibit the COX-1 enzyme which has a toxic effect on membrane permeability in the gastrointestinal system. This study was conducted to determine the association between the use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and H. pylori infection on the incidence of peptic ulcers.

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