Cisplatin is an effective anti-neoplastic agent, that could be used against many types of cancers. Even high dosages of cisplatin are more effective, there is a concern due to their toxic side effects especially on renal tissue. The harmful effects of cisplatin were resulted in oxidative stress, apoptosis and also DNA damage. Ferulic acid (FA), is a plant phenolic acid that turns out to be a potential antioxidant phenoxy radical. Phenolic compounds are known for their roles on neurodegenerative diseases, cancer, diabetes, coronary heart diseases, inflammation states and idleness as potential therapeutic agents. It has been already reported that FA with its antioxidant properties is able to neutralize nitric oxide and hydroxy-radical groups that lead to DNA damage.