Creutzfeldt –Jakob Disease (CJD) is an exceptional, degenerative, and continually deadly brain disorder achieved by prion proteins that affect abnormal imploding of conventional frontal cortex proteins. This misfolding prompts mind damage and brand name aftereffects, including rapid moderate dementia, myoclonus, visual agitating impacts, and ataxia. Regardless of its special case, CJD presents basic expressive hardships due to its aftereffect get over with other neurodegenerative diseases. This case report looks at a 58-year-old patient with moderate mental deterioration, visual disrupting impacts, and direct changes more than a half year, highlighting the crucial occupation of MRI in diagnosing CJD. Key MRI revelations included diffusion restriction and T2/FLAIR hyperintensities in the separate corpus striatum, forward looking, parietal, and occipital cortices, with commonplace thalami, which immovably maintained the examination of CJD. These radiological encounters feature the meaning of forefront neuroimaging techniques in isolating CJD from various conditions and working with early finding and the leaders.