The Present study aimed in analyzing the impact of clinical pharmacist interventions over anti tubercular treatment strategies in management of drug related problems for the achievement of desired therapeutic outcomes in effective combating of tuberculosis which got approval from District TB Office in Jayanagar 4th Block, Bangalore, Karnataka ,India and data regarding the tuberculosis patients visiting the RNTCP/DOTS centers of PHCs located in North Bangalore (RT Nagar area (Cholanayakanahalli, Sulthan palya, Hebbal),Herohalli,Devanahalli,Yelahanka was collected during May 2022 to May 2024 over a period of 2 years, where a sample size of 999 was analyzed by using PCNE Classification scheme for Drug-Related Problems V9.01 and founded that P1 -673 (67.36) of Adverse drug reactions,P2-105(15.01),Drug choice problems,P2.1-42(4.242) Duplication of therapeutic group, P2.2 -31(3.103) Inappropriate drug Form, P2.3-17(1.701)No clear indication of Drug, P3-9(0.900) Drug use problems, P3.1-104(10.410) Drug overused / over Administered, P4-524(52.45) Drug interaction,P5.1-171(17.11) Insufficient awareness of health and diseases all the details regarding the drug related problems were reported to risk factors and ADR s will be managed monitored documented and reported to RNTCP staff and necessary interventions were carried out in promotion of desired therapeutic outcome to END TB and same reports were sent to state TB Control office for the future references. The Present study concludes that the clinical pharmacist’s timely interventions in the Prescription analysis and patient's drug therapy is required for the effective management of drug related problems in promotion of rational drug usage and achievement of desired therapeutic outcomes.