Cocrystallization, an emerging field at the intersection of chemistry, materials science, and pharmaceuticals, has garnered significant attention due to its potential applications in enhancing drug solubility, improving material properties, and enabling novel chemical syntheses. This review provides a comprehensive analysis of the fundamentals, recent advances, and applications of cocrystallization. We delve into the basic principles of cocrystallization, exploring the key components and various methodologies employed in this process. Recent developments in cocrystallization research, including innovative techniques and analytical tools, are discussed to highlight the dynamic nature of the field. The review also emphasizes the diverse applications of cocrystallization across different scientific domains, showcasing its pivotal role in drug formulation, materials design, and chemical synthesis. Through a series of case studies, we illustrate successful cocrystallization applications, analyzing methodologies and outcomes. Additionally, we conduct a comparative analysis of different cocrystallization methods, elucidating their advantages, limitations, and contextual relevance. Challenges associated with cocrystallization are identified, and potential avenues for future research are explored. The abstract concludes by summarizing key insights and advocating for the continued exploration of cocrystallization as a promising avenue for scientific and technological advancements.