INTRODUCTION: Dentofacial diseases that can result from extra- or intraarticular disease are known as temporomandibular joint disorders (TMD). Steroids, muscle relaxants, and non-steroidal anti-inflammatory medicines (NSAIDs) are among the medications used to treat TMD. To lessen symptoms and delay the disease's evolution into a chronic illness, many of these medications are used in combination. AIMS and OBJECTIVES: This study aims to compare the effect of conventional treatment (ibuprofen) with ibuprofen+ omega 3 in the treatment of temporomandibular joint disorder. METHODOLOGY: Double blind randomized control trial was carried out on TMJ patients who attended the oral medicine and outpatient departments of Peshawar Dental College (PDC) and Khyber College of Dentistry (KCD). Total 116 patients were randomly allocated into two groups, each group having 58 patients. The Numerical Rating Scale (NRS) for pain was one of the self-structured questionnaires used to gather the data. Prior to the start of the treatment, the pain was noted on day 0. In control group i.e conventional treatment group 400 mg of ibuprofen BD was administered to the patients. Whereas Ibuprofen 400mg BD along with omega 3 1000mg OD was given to the experimental group. The medications were given to the subjects of both groups for a total of thirty (30) days. After 7, 15, and 30 days, the patients were recalled to evaluate their response to the medications. The statistical analysis was conducted using the Mann Whitney U test. Results: At the end of the trial comprehensive relief from various types of severe pain was observed in both groups, but experimental group (Ibuprofen + Omega 3) attained this target prior to control group (Ibuprofen alone).