To assess the efficacy of cone-beam computed tomography (CBCT) in comparison to computed tomography (CT) in the radiographic evaluation of various osseous lesions in the maxillofacial region. Materials and Methods: The study was conducted on 25 subjects with osseous lesions in the maxillofacial region diagnosed by histopathology who were subjected to CT and CBCT as a part of their diagnostic workup. The image pairs were obtained from the departmental archive and were compared for diagnostic quality and dimensional accuracy. Statistics: Descriptive statistical analysis was carried out for all the parameters in this study. The data collected were tabulated and subjected to statistical analysis using the software Stata version 13.1 and SPSS version 20 for Windows (SPSS Inc., Chicago, IL, USA) to obtain the results. Results:The results of the study showed that CBCT showed more accuracy in comparison to CT in the evaluation of osseous maxillofacial lesions. Discussion: The results from the present study showed that CBCT could provide an image with CT-comparable and sometimes superior diagnostic quality and accuracy in case of osseous lesions, with a lesser radiation dose and risk, at a lower cost.