Yashada bhasma has proven significant efficacy in the treatment of diseases such as diabetes, eye disorder, urine disorder, and others. As bhasma is a metallic preparation, its quality must be proven, various classical as well as modern techniques are available for that among them are XRD, DLS, SEM and EDAX etc. Yasad bhasma containing zinc, Zinc has a distinct biological function, and its deficiency leads to many kinds of diseases. Hence, the present work deals the analysis of Yasad bhasma of three different brands, to compare and know the quality. Yasad bhasma were purchased from local Ayurvedic market Amravati, India. of three manufacturers, namely Shree Baidyanath (BYB), Shree Dhutpapeshwar (DYB) and Unjjha pharmaceuticals (UPYB). Based on a study, the classical method (BYB and DYB) produce better results; therefore, both samples should be proceed for analytical analysis. The XRD analysis of both bhasma samples reveals a hexagonal ZnO crystalline phase, stability is confirmed by the zeta potential value, and the element zinc is the main constituent in addition to Fe, Pb, Cu, Sn, Mg, and Mn. by atomic absorption spectroscopy. ZnO, C=C, OH functional groups in both samples confirm by FTIR. DYB shows less particle size than BYB. So bioavailability of Dhootpapeshwar Yashada bhasma was greater. By analytical method of examination along with classical method this is reveal that DYB is better for therapeutic efficacy. This step towards establishing significant move in revealing the scientific explanations for the safety and effectiveness of this traditional medical practice.