In the context of lowering levels of low-density lipoprotein cholesterol (LDL-C) and assisting in the prevention of cardiovascular disease (CVD), the objective of this abstract is to study the contemporary molecular mechanisms and health benefits associated with plant-based natural foods and phytochemicals. The numerous molecular pathways that are involved are the primary focus of this review. These pathways include the control of lipid metabolism, inflammation, oxidative stress, and endothelial function, among others. In addition, it highlights the wide variety of bioactive substances that are found in plant meals. These compounds include polyphenols, flavonoids, and carotenoids, all of which have the capacity to considerably lower levels of LDL-C and possess cardioprotective qualities. Furthermore, the purpose of this inquiry is to investigate the growing significance that epigenetic modifications brought about by phytochemicals play in the regulation of gene expression in relation to the maintenance of cholesterol homeostasis and the proper functioning of the cardiovascular system. An in-depth explanation of these mechanisms is provided in this abstract, which highlights the significance of adding plant-based dietary treatments that are abundant in phytochemicals as a potentially effective method for the management of dyslipidaemia, the reduction of the risk of cardiovascular disease, and the promotion of general cardiovascular health.