Various studies suggest that there has been an increase in the number of cases of sepsis in children in the last two decades, which may be associated with increased survival and morbidity, especially in children. Children living in low-income countries with malnutrition become a great population that is vulnerable to sepsis. Zinc is one of the trace elements that can modulate innate and adaptive immune system. It was believed zinc could be a biomarker to predict sepsis outcome as well as zinc supplementation for reducing sepsis severity. This observational analytic study was conduct in RSUP Prof. Dr. R. D. Kandou Manado for four months with total samples of 57 children aged 1 to 18 years old. The result showed that there was a significant relationship between zinc levels and increase morbidity in children (p-value < 0.001). Zinc serum levels at the time of diagnosis of sepsis can be used as an indicator of the outcome of sepsis in children.