INTRODUCTION: Darier’s disease is a rare genetic skin disorder characterized by multiple hyperkeratotic, greasy papules primarily affecting seborrheic areas, associated with nail abnormalities and mucous membrane involvement. It follows an autosomal dominant inheritance pattern due to mutations in the ATP2A2 gene, impacting calcium signalling and cellular adhesion. CASE SERIES: This study presents four cases of Darier’s disease, showcasing the diverse clinical spectrum of the disease. Cases 1, 2, and 3 depict the typical presentation of the disease with chronic, relapsing keratotic papules exacerbated by sun exposure and other factors, while emphasising the familial inheritance patterns. Case 4 highlights a rare Type 1 segmental variant with unilateral distribution along the lines of Blaschko. CONCLUSION: Diagnosis of Darier’s disease relies on clinical evaluation and histopathological examination which crucial for differentiating Darier’s disease from other dermatoses and to provide insight to the patients about its hereditary implications. Treatment options, including topical and systemic therapies alongside lifestyle modifications, aim to manage symptoms and improve patient quality of life despite the lack of a definitive cure.