Objective: The primary objectives of this study are to find the incidence ratio and percentage of hypothyroidism and PCOS in infertile females, the impact of these endocrine conditions on reproductive health, and explore the interrelation between hypothyroidism and PCOS with each other and with infertility. Methods: A prospective study of 4 months was conducted at Central Park Teaching Hospital in which 43 women aged 18-45 presenting with PCOS, hypothyroidism, or both were enrolled. These females underwent diagnostic evaluation for PCOS and examination of TSH levels based on the Rotterdam criteria, 2003. Males, women outside of the reproductive age window, women undergoing fertility treatments, chronically ill patients, and those having thyroid disorders other than hypothyroidism were among the exclusion criteria. The data was analyzed statistically to understand the prevalence and relationship between PCOS, hypothyroidism, and infertility. Ethical approval and informed consent were obtained. Results: 5-7% of the infertile females suffered from subclinical hypothyroidism whereas the prevalence of PCOS was greater than 70-80% of the females. 11-36% of the females diagnosed with PCOS were also found to have hypothyroidism causing infertility. The data suggested that women suffering from these conditions exhibit a greater risk of infertility, along with menstrual irregularities, hormonal imbalances, and metabolic dysfunctions. Conclusion: These findings highlight the importance of the coexistence of the intricately interlinked pathologies: PCOS, hypothyroidism, and infertility and how they aggravate reproductive difficulties, suggesting the need for appropriate diagnostic and therapeutic approaches. Importance: This study signifies the need for a holistic diagnostic approach, improved reproductive health outcomes, and early detection and treatment of PCOS and hypothyroidism to maintain a balance of hormones and improve fertility. It also provides valuable insights for future research and public health strategies.