Background: Malignant bone and cartilage neoplasms pose significant clinical challenges despite diagnostic and treatment advancements. Understanding their epidemiology, clinical characteristics, and histopathological features is crucial for accurate diagnosis and treatment. Further investigation into their incidence, distribution, and clinicopathological correlations, particularly in diverse patient populations is warranted. Introduction: This study aims to complete the analysis of malignant neoplasms of bone and cartilage, including a broad collection of tumours with a wide range of non-specific symptoms. An accurate and quick diagnosis is required to treat all tumours effectively and early on to reduce the disease’s effects. This study is conducted to investigate the demographic, clinical, radiological and histopathological distribution of various malignant bone tumours in a tertiary care hospital. Methodology: This is a retrospective cross-sectional study conducted in the Department of Pathology at Sri Ramachandra Medical College and Research Institute from January 2020 to December 2023 with 106 study samples. Their sampling method involved demographic details, clinical history, histopathological data collected from archived slides and data collection for radiographic images, hospital records and the PACS system. The distribution of age, sex, and different types of various malignant neoplasms of bone and articular cartilage in different anatomical sites were obtained and statistical analysis were done. Results: Primary tumours accounted for 76 cases (71.6%), while secondary tumours constituted 30 cases (28.3%). In this study, the distribution of histopathological diagnosis was as follows: Osteosarcoma was observed (n=39;51.3%), Ewing's sarcoma (n=20; 26.3%), Chondrosarcoma(n=16; 21%), malignant GCT(n=1;1%) and metastasis(n=30; 30%). Osteosarcoma is observed in 39 cases, with the highest numbers in the Femur (19 cases), followed by Tibia (8 cases), Humerus (8 cases), and Radius (4 cases). Secondaries (metastasis) was observed most commonly involving vertebra in 16 cases (54%) followed by sacrum in 5 cases (17%), femur in 4 cases (13%), knee in 3 cases (10%), manubrium sternum in 2 cases (6%). Conclusion: This study gives a descriptive analysis of the distribution of malignant bone and cartilage tumours in a tertiary care setting in south India and also emphasises the importance of a multidisciplinary approach to arrive at an accurate diagnosis for tailored treatment