Background Dental caries is a prevalent oral health issue that significantly impacts an individual's quality of life. This study aims to explore the relationship between dental caries experience and oral health-related quality of life (OHRQoL) in adults, identifying key factors that influence this association. Materials and Methods A cross-sectional study was conducted among 300 adults aged 18-65 years in [Location]. Participants were selected using a stratified random sampling method. Dental caries experience was assessed using the Decayed, Missing, and Filled Teeth (DMFT) index. OHRQoL was measured using the Oral Health Impact Profile (OHIP-14). Data on socio-demographic factors and oral health behaviors were also collected through structured questionnaires. Statistical analysis was performed using SPSS software, with a significance level set at p < 0.05. Results The mean DMFT score among participants was 8.5 (SD ± 3.2). A significant correlation was found between higher DMFT scores and lower OHRQoL scores (r = -0.56, p < 0.01). Participants with higher caries experience reported more frequent issues such as pain (65%), difficulty in eating (72%), and social interaction problems (58%). Age, income, and educational level were significant predictors of OHRQoL (p < 0.05). Oral hygiene practices, including brushing frequency and dental visits, were associated with better OHRQoL outcomes.