Background: Using restraint in critically ill patients is a complex decision and related to patient criteria, environment and care providers. Aim: Explore anxiety, depression and stress level among ICU restrained patients and their related factors. Method: A descriptive correlational design was conducted for this study, which implemented in intensive care units at Egypt of Health care Authority, Port Said hospitals. A purposive sample of 129 adult ICU restrained patients was enrolled in the current study. One instrument was used in this study Results: The study results revealed that restrained patients in ICU suffered from psychological effect like anxiety, depression and stress. Additionally, patients previous hospitalization related significantly to anxiety and stress with P-Value of (0.020, and 0.002) respectively. Moreover patient violence during restrain related significantly to anxiety, depression and stress with P-Value of (0.021, 0.023, and 0.023) respectively. Conclusion: Results of the current study concluded that anxiety is the highest psychological effect among restrained patients. However, patient violence during restrain related significantly to anxiety, depression and stress.