Background: Reproductive health is one of the most pressing public health issues of the 21st century necessitating a multi-dimensional response. The most prevalent endocrine disorder affecting reproductive females is PCOS. It has a wide range of clinical implications including both psychological distress and reproductive symptoms. Aim & Objectives: The aim of the study is to assess the level and relationship of Depression, Anxiety, Stress and Quality of Life among women with PCOS. Materials & Methods: 110 women with Confirmed diagnosis of PCOS were taken from Santosh Medical College and Hospital. Tools used were Depression Anxiety Stress Scale (DASS-42) and Quality of Life scale (QOL-SSNN) were administered. Results: The significant correlations found in this study highlight the close interrelation of Depression, Anxiety, Stress and their inverse relationship with Quality of Life among women with PCOS. It indicates that as Depression, Anxiety and Stress increases the Quality of Life tends to decrease. Conclusion: These findings underscore the importance of addressing mental health issues in PCOS women. Recognizing and addressing the mental health aspects of PCOS is crucial by addressing the mental health component of PCOS healthcare providers may enhance the overall well-being of women with this condition promoting a more comprehensive and patient-centered approach to healthcare.