This work aimed to develop an anti-diabetic transdermal patch incorporating hydroethanolic extract of Morus alba leaves which has well proven hypoglycemic properties. The bioactive components of Morus alba leaves are apigenin, quercetin, and rutin which have proven anti diabetic activities. Using the solvent casting approach, herbal transdermal patches were manufactured with Eudragit RL 100 and PVP K 30 polymer. Different polymer ratios serve as a framework for the development of five formulations (F1-F5). Flexibility, thickness, weight variation, flatness, surface pH, folding endurance, percent moisture content, percent moisture uptake, and tensile strength were among the physicochemical properties assessed. The amount of drug was determined using spectrophotometry at wavelength 330 nm. A transdermal patch drug release study was conducted using the paddle over disc method using a 500 mL phosphate buffer pH 7.4. All five batches were seen to be opaque and non-sticky in nature based on the appearance results. The patches' surfaces were smooth. The addition of the hydrophilic polymer PVP K 30 in the right amount increases the medication release in F5. The results of the stability investigation indicated that F5 performed admirably for 180 days in the accelerated conditions. There were no discernible changes in the appear, drug content, or in-vitro release of medications after 24 hours in the previously indicated conditions.