Objectives: This study aims to create 3D QSAR models to confirm the antioxidant and anti-tyrosinase activity of indolo[3,2-c] quinoline analogs and determine nearly all appreciative structural features in contemplation of developing novel medicinal medicines. Methods: To appraise predicted precision of the QSAR framework, the datasets were split into a training set and test set. The training set encompasses 39 analogs, chosen randomly, whereas the test set comprised 10 analogs. The chemicals were selected to guarantee a variety of structures and a broad spectrum of biological effects in the dataset. The IC50 values were transformed into pIC50 to get higher numerical values.