Diabetes Type 1 diabetes is a notable condition impairing the body's control over blood sugar levels, in this condition, the body lacks the production of insulin, an essential hormone for maintaining normal In type 2 diabetes, the cells in the body become resistant to insulin, resulting in higher blood glucose levels, a condition known as hyperglycemia. Prolonged hyperglycemia is associated with severe Long-term complications such as retinopathy (damage to the eyes) and neuropathy, affecting both small and large blood vessels. Finding new, safe, and effective treatments for diabetes remains a major challenge for researchers. Based on an extensive review of existing studies, we chose to design and synthesize new antidiabetic agents. Using the iGEMDOCK program, we performed docking, screening, and analysis of the compounds targeting the 5TWV protein