The current work presents a novel, fast, eco-friendly, and straightforward method for biologically synthesizing silver nanoparticles loaded nanogel using Liquorice (Glycyrrhiza glabra Lin.) root extract. In order to create stable silver nanoparticles through a biological reduction method, an aqueous stock solution of Liquorice extract was created and employed as a capping and reducing agent. Response surface analysis (RSA) based Box-Behnken design (BBD) was used to systematically optimize the method, accounting for the effects of temperature, reaction time, and concentration of silver nitrate (AgNO3) on response